Mathematical modelling of whole chromosome replication

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Mathematical modelling of whole chromosome replication

All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins. Here we investigate how the activity of multiple origins on each chromosome is coordinated to ensure successful replication. We present a stochastic model for whole chromosome replication where the dynamics a...

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Before a cell divides into two daughter cells, its entire genetic material has to be copied without errors and exactly once. In eukaryotic cells, a vast amount of replication origins exists that enable the replication of the DNA to initiate simultaneously from many origins in parallel, thereby contributing to a relatively rapid duplication of the genome. The initiation of DNA replication from t...

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mathematical modelling of pulmonary edema

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2010

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gkq343